Clinical Trials

I am a person who has had to remain in “maintenance” chemo for almost seven years. During this time I have grown to deeply appreciate the caregiving and caring provided at PVHO.

CLINICAL TRIALS AVAILABLE IN THE PHOENIX AREA

Myelodysplastic Syndrome:

TetraLogic 0087
A Phase 1b/2a, Open-label, Non-randomized Study of Birinapant in Combination with 5-azacitidine in Subjects with Myelodysplastic Syndrome who are Naïve, Refractory, or have Relapsed to 5-azacitidine Therapy.

 

Higher Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia:

TetraLogic 0094
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Azacitidine with or without Birinapant with a Single Arm Open-Label Run-In Phase in Subjects with Higher Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia.

 

Pancreatic Cancer:

Incyte INCB18424-362
A Randomized, Double-Blind, Phase 3 Study of the JAK1/2 Inhibitor, Ruxolitinib or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy.

 

Non Hodgkin Lymphoma:

Infinity IPI-145-06
A Phase 2 Study of IPI-145 in Subjects with Refractory Indolent Non-Hodgkin Lymphoma.

 

Triple-Negative Breast Cancer:

Celldex CDX011-04
The primary objective of the study is to evaluate the anti-cancer activity of CDX-011 in metastatic, GPNMB over-expressing, triple-negative breast cancer as measured by the duration of progression-free survival (PFS).

 

HER2-Positive Breast Cancer:

Merrimack MM-302-02-02-03
Patients with incurable, unresectable, locally advanced/metastatic HER2-positive breast cancer patients who have received prior treatment with trastuzumab in any setting and who have either progressed on or are intolerant to each of pertuzumab and ado-trastuzumab emtansine in the metastatic or locally advanced setting. Patients must not have been previously treated with an anthracycline in any setting.

 

Triple Negative Breast Cancer:

Celgene ABI-007-MBC-001
First-line treatment of subjects with triple negative metastatic breast cancer (TNMBC), defined as estrogen receptor (ER) negative, progesterone receptor (PgR) negative, and human epidermal growth factor receptor 2 (HER2) negative.

 

Non Small Cell Lung Cancer:

Celgene ABI-007-NSCL-003
This is a Phase III, randomized, open-label, cross-over, multi-center study of nab-paclitaxel or best supportive care (BSC) as maintenance treatment after response or SD with nab-paclitaxel plus carboplatin as induction in subjects with squamous cell NSCLC. Once a subject in the BSC arm during the Maintenance part of the study
experiences radiologic progression of disease, they will be eligible to cross-over to receive nabpaclitaxel.

Genentech MO22097
An open-label, randomized, Phase IIIb trial evaluating the efficacy and safety of standard of care ± continuous bevacizumab treatment beyond progression of disease (PD) in patients with advanced non-squamous non-small cell lung cancer (NSCLC) after first (1st)-line treatment with bevacizumab plus a platinum doublet-containing chemotherapy.

 

For questions or for more information please contact us at your preferred location, or schedule an appointment with one of our medical oncologists.

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